Foundation models are reshaping computational biology. Pretrained on massive corpora of protein or genomic sequences, models such as ESM2 (a protein language...

Foundation models are reshaping computational biology. Pretrained on massive corpora of protein or genomic sequences, models such as ESM2 (a protein language model) and Evo 2 (a DNA language model) capture statistical regularities of biological sequences. These transfer well to a wide range of downstream tasks, including structure prediction, variant effect, and functional annotation.

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As AI infrastructure scales, enterprise expectations for operational maturity are increasing. Organizations expect these systems to be provisionable,...

As AI infrastructure scales, enterprise expectations for operational maturity are increasing. Organizations expect these systems to be provisionable, observable, secure, and manageable at scale—the same standard applied to all critical infrastructure. The moment an AI system moves from development into enterprise deployment, that operational foundation is essential. NVIDIA DGX Spark and…

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This post is the third of a three-part series. See also Model Quantization: Concepts, Methods, and Why It Matters and Model Quantization: Post-Training...

This post is the third of a three-part series. See also Model Quantization: Concepts, Methods, and Why It Matters and Model Quantization: Post-Training Quantization Using NVIDIA Model Optimizer. Converting a quantized checkpoint into an NVIDIA TensorRT engine bridges the gap between model optimization and production deployment, enabling faster inference, higher throughput…

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Federated learning (FL) research often begins with a deceptively simple question: What should we try next? A new aggregation rule, a FedProx coefficient, a...

Federated learning (FL) research often begins with a deceptively simple question: What should we try next? A new aggregation rule, a FedProx coefficient, a server optimizer setting, a SCAFFOLD variant, or a model architecture tweak may all look promising before an experiment starts. After the run finishes, the harder questions begin: Did the change actually improve the metric?

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Developers can now use NVIDIA CUDA Tile programming within large existing C++  GPU codebases to develop highly optimized GPU kernels using tile-based...

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NVIDIA CompileIQ tackles one of the hardest problems in performance engineering: finding the compiler options that unlock the best performance for a specific...

NVIDIA CompileIQ tackles one of the hardest problems in performance engineering: finding the compiler options that unlock the best performance for a specific workload. Consider a team that has spent weeks optimizing an LLM inference pipeline on GPUs, tuning batch sizes, quantizing to FP8, adopting flash attention, fusing every kernel they can. The profiler says there’s nothing left to squeeze.

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This post is the second of a three-part series. See also Model Quantization: Concepts, Methods, and Why It Matters and Model Quantization: Turn FP8 Checkpoints...

This post is the second of a three-part series. See also Model Quantization: Concepts, Methods, and Why It Matters and Model Quantization: Turn FP8 Checkpoints into High-Performance Inference Engines with NVIDIA TensorRT. Model quantization is an effective method to reduce VRAM usage and improve inference performance on consumer devices such as NVIDIA GeForce RTX GPUs.

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Distributed deep learning depends on fast, reliable GPU-to-GPU communication using the NVIDIA Collective Communication Library (NCCL). When training slows down,...

Distributed deep learning depends on fast, reliable GPU-to-GPU communication using the NVIDIA Collective Communication Library (NCCL). When training slows down, it becomes challenging to determine why and what to do next. A problem can span computation, communication, a specific rank, or underlying hardware. NVIDIA NCCL Inspector accelerates triaging by providing a lightweight and continuous…

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Modern supply chains operate under the constant pressures of fluctuating demand, volatile costs, constrained capacity, and interdependent decision-making....

Modern supply chains operate under the constant pressures of fluctuating demand, volatile costs, constrained capacity, and interdependent decision-making. Traditionally, specialized operations research (OR) teams solved these problems by translating business questions into mathematical models. This process can take weeks and often produces fragile solutions that struggle to adapt when conditions…

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NVIDIA CUDA Tile (cuTile) is a tile-based programming model that enables developers to write GPU kernels in terms of tile-level operations—loads, stores, and...

NVIDIA CUDA Tile (cuTile) is a tile-based programming model that enables developers to write GPU kernels in terms of tile-level operations—loads, stores, and matrix multiply-accumulate—rather than manually coordinating threads, warps, and shared memory. cuTile.jl brings the same tile-based approach to the dynamic programming language Julia. Users can write custom GPU kernels without dropping…

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For decades, computational biology has operated under a reductionist compromise. To fit complex biological systems into the limited memory of a single GPU,...

For decades, computational biology has operated under a reductionist compromise. To fit complex biological systems into the limited memory of a single GPU, researchers have had to deconstruct them into isolated fragments—single proteins or small domains. This created a context gap, where larger proteins or complexes could not be folded zero-shot due to GPU hardware memory constraints. Now…

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The subsurface industry is at a critical point in its digital evolution. For decades, unlocking reservoir potential has relied on experts performing essential...

The subsurface industry is at a critical point in its digital evolution. For decades, unlocking reservoir potential has relied on experts performing essential and time-intensive manual workflows. As data complexity grows, the gap between machine speed and human bandwidth has become a primary bottleneck. On-demand simulation workflows are currently hampered by both manual data overhead…

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Federated learning (FL) is no longer a research curiosity—it’s a practical response to a hard constraint: the most valuable data is often the least movable....

Federated learning (FL) is no longer a research curiosity—it’s a practical response to a hard constraint: the most valuable data is often the least movable. Regulatory boundaries, data sovereignty rules, and organizational risk tolerance routinely prevent centralized aggregation. Meanwhile, sheer data gravity makes even permitted transfers slow, expensive, and fragile at scale.

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In March 2026, three LLM agents generated over 600,000 lines of code, ran 850 experiments, and helped secure a first-place finish in a Kaggle playground...

In March 2026, three LLM agents generated over 600,000 lines of code, ran 850 experiments, and helped secure a first-place finish in a Kaggle playground competition. Success in modern machine learning competitions is increasingly defined by how quickly you can generate, test, and iterate on ideas. LLM agents, combined with GPU acceleration, dramatically compress this loop. Historically…

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As LLMs transition from simple text generation to complex reasoning, reinforcement learning (RL) plays a central role. Algorithms like Group Relative Policy...

As LLMs transition from simple text generation to complex reasoning, reinforcement learning (RL) plays a central role. Algorithms like Group Relative Policy Optimization (GRPO) power this transition, enabling reasoning-grade models to continuously improve through iterative feedback. Unlike standard supervised fine-tuning, RL training loops are bifurcated into two distinct, high-intensity phases: a…

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